Systematic Review of Cost-Effectiveness Analysis for Surgical and Neurostimulation Treatments for Drug-Resistant Epilepsy in Adults

N Ngan Kee; E Foster; C Marquina; A Tan; SST Pang; TJ O'Brien; P Kwan; GD Jackson; Z Chen; Z Ademi

Journal article

Systematic Review of Cost-Effectiveness Analysis for Surgical and Neurostimulation Treatments for Drug-Resistant Epilepsy in Adults

N Ngan Kee, E Foster, C Marquina, A Tan, SST Pang, TJ O'Brien, P Kwan, GD Jackson, Z Chen, Z Ademi

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2023

DOI: 10.1212/WNL.0000000000207137

Abstract

Background and ObjectivesSurgical and neurostimulator treatments are effective for reducing seizure burden in selected individuals living with drug-resistant epilepsy (DRE). We aimed to determine the presence and key model determinants for cost-effectiveness of these interventions, compared with medical management alone, to assist with decisions about resource allocation.MethodsA systematic literature search was conducted on June 1, 2022, using MEDLINE, EMBASE, the NHS Economic Evaluation Database, and the Cost-Effectiveness Analysis database. Included studies were economic evaluations in adult DRE cohorts, comparing surgical and neurostimulator treatments (vagus nerve stimulation [VNS], res..

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University of Melbourne Researchers

Patrick Kwan Author

Graeme Jackson Author

Related Projects (1)

PRECISION MEDICINE IN EPILEPSY

Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This work was supported by an Australian Government Medical Research Future Fund Frontier Health and Medical Research Program Stage Two grant (MRFF75908) and a NHMRC Investigator Grant to T.J. O'Brien. (APP1176426). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.